Structure and post-translational modification of the prostaglandin transporter.

ABSTRACT: The prostaglandin transporter (PGT) is a member of the OATP family of membrane transporters. PGT mediates the uptake of prostaglandins from the extracellular environment to enable intracellular enzymatic degradation and termination of signaling. In addition to importing prostaglandins, PGT is also an essential core component of the Maxi-Cl channel, which facilitates cellular release of ATP and other small organic anions. Despite progress on understanding the (patho)physiological roles of PGT, and development of small molecules to inhibit this transporter, molecular details of the overall structure and transport mechanism remain elusive. Here we determined the cryo-EM structure of human PGT, which demonstrates an overall topology consistent with other OATPs despite possessing a dual transpo

SUBMITTER: Yu P 

PROVIDER: S-EPMC12274398 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature