Rising prevalence of Plasmodium falciparum Artemisinin partial resistance mutations in Ethiopia.

ABSTRACT:

Background

Ethiopia aims to eliminate local malaria transmission by 2030, but rising malaria cases, due to different factors, present a challenge. Understanding the prevalence and distribution of artemisinin partial resistance (ART-R) and other markers related to partner drugs as well as parasite connectivity in Ethiopia can greatly inform malaria control.

Methods

We analyzed 1199 clinical Plasmodium falciparum infections from 12 sentinel sites across five regions in Ethiopia, collected between 2019 and 2023. Using two molecular inversion probe (MIP) panels targeting key drug resistance genes and genome-wide SNPs, we assessed the prevalence of resistance-associated mutations, complexity of infection (COI), and parasite relatedness through identity-by-descent (IBD) and princi

SUBMITTER: Brhane BG 

PROVIDER: S-EPMC12274420 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature