Effect of conditioned stimuli-triggered memory retrieval-extinction in patients with methamphetamine use disorder.

ABSTRACT: Methamphetamine (METH) is a widely abused stimulant that affects the central nervous system. The persistent maladaptive conditioned stimuli (CS, drug cues)-drug associative memories represent a primary factor precipitating relapse. Interfering with the reconsolidation of these memories may help disrupt and modify these maladaptive CS-drug associations, potentially reducing their influence on drug-seeking behavior. The present study explored the effect of CS-triggered memory retrieval-extinction on METH craving, potentially offering a new treatment strategy for addiction. This was a single-center, randomized, controlled trial involving individuals with METH use disorder (MUD). Participants completed one of three interventions on consecutive days (days 2 and 3): CS-triggered memory retrieval

SUBMITTER: Yue JL 

PROVIDER: S-EPMC12274424 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature