Childhood maltreatment, exercise and transition to bipolar disorder among major depressive disorder patients.

ABSTRACT: Early and accurate identification and management of bipolar disorders (BDs) among major depressive disorders (MDDs) in clinical practice would place these patients in progressive early-onset bipolar care. The associations between childhood maltreatment, exercise and transition from MDD to BD remain unclear. To determine whether MDD patients reporting childhood maltreatment are at an increased risk of transition to BD. The secondary objective is to evaluate the moderating effects of exercise on the association. This prospective cohort study with a maximum follow-up of four years was based on the Depression Cohort in China. 1392 MDD with 18-65 years of age were enrolled between March 2019 and November 2023 after diagnosis by trained psychiatrists using the Mini-International Neuropsychiatric

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12274479 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature