Network toxicology combined with molecular docking technology to explore the molecular mechanism of amatoxin causing liver injury.

ABSTRACT: As one of the most toxic molecules in the fungal kingdom, amatoxin exhibit exceptional thermal stability and acid resistance. Once ingested, these compounds are rapidly absorbed and transported unimpeded to vital organs. They disrupt cellular metabolism by inhibiting nucleic acid and protein synthesis in target organs, ultimately causing hepatic and renal necrosis. Without prompt intervention, this molecular sabotage can progress to multiorgan failure and death. Early diagnosis combined with aggressive therapeutic measures is crucial for mitigating acute hepatic damage and significantly improving survival outcomes. This study aims to elucidate the molecular mechanisms underlying amatoxin-induced hepatic injury and establish a theoretical framework for targeted therapeutic interventions. Co

SUBMITTER: Wang C 

PROVIDER: S-EPMC12274506 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature