Myc overexpression improves recovery from myocardial infarction associated with cardiomyocyte hyperplasia in the mouse heart.

ABSTRACT: Adult mammalian hearts lack the ability to regenerate after a myocardial infarction, which leads to heart failure progression. Therefore, finding ways to promote regeneration is a major goal in the development of cardiovascular therapies. In this study, we focus on the role of Myc moderate overexpression in response to acute ischemic injury. We have previously shown that moderate Myc overexpression is not detrimental to cardiac function and promotes cell competition and a hyperplastic phenotype. Here, we describe that Myc overexpression in non-regenerative postnatal hearts promotes functional improvements and reduced scar formation after myocardial infarction. This response correlates with a hyperplastic phenotype in postnatal and adult hearts, characterized by bigger hearts, smaller cardi

SUBMITTER: Villa Del Campo C 

PROVIDER: S-EPMC12274510 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature