Design, synthesis and medical prospects of electrospun molecularly imprinted fibers.

ABSTRACT: The current study describes fabrication of molecularly imprinted (MI) electrospun nanofibers of average diameter 500 nm for controlled delivery of two templates; ferulic acid (FA) and khellin. Polycaprolactone (PCL) was used as supporting matrix in fiber preparation while polyallylamine (PAM) was added to provide molecular recognition sites for the template. The preparation of MI fibers was optimized using design of experiments (DoE). For FA fibers, a fractional factorial deign was used to screen different factors involved in the electrospinning process and it was found that FA and PAM concentration; in addition to PCL concentration were significant. These two variables were used to create a central composite design to optimize fiber diameter. Control fibers were prepared by directly loadi

SUBMITTER: Megahed SH 

PROVIDER: S-EPMC12274513 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature