Bidirectional relationship between anemia and cognitive function in middle-aged and older Chinese adults: a longitudinal study.

ABSTRACT: The increasing prevalence of anemia and cognitive decline among middle-aged and older adults poses significant public health challenges. While most studies have examined the impact of anemia on cognition, the potential for a bidirectional relationship, where cognitive function also influences anemia risk, remains less explored, particularly via longitudinal designs and advanced modeling. Therefore, we utilized data from 4521 participants (women = 2434, men = 2087) from the initial (2011-2012) and subsequent (2015-2016) waves of the China Health and Retirement Longitudinal Study (CHARLS). We measured hemoglobin levels, global cognitive function, and other factors. Linear regression was used to analyze the association between baseline anemia status and follow-up cognitive function in partici

SUBMITTER: Xiong J 

PROVIDER: S-EPMC12274517 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature