Severity of atopic dermatitis is associated with gut-derived metabolites and leaky gut-related biomarkers.

ABSTRACT: Dysbiosis of the gut microbiota may contribute to metabolic dysregulation, intestinal barrier disruption, and inflammatory disorders. The objective was to identify gut-derived metabolites and leaky gut biomarkers linked to atopic dermatitis. Fifty adult patients with atopic dermatitis and 25 controls were studied. Blood levels of 30 biomarkers were analyzed using liquid chromatography-mass spectrometry, ELISA, and Luminex assays, and correlated with clinical outcomes (EASI, SCORAD, extent of skin lesions). We discovered higher concentrations of caproic acid, glycerophosphocholine, Reg3A, I-FABP, IL-10, and IL-22 in patients with atopic dermatitis compared to controls, while the concentration of trimethylamine was lower. Disease severity was associated with lower caproic acid and isocaproic

SUBMITTER: Blicharz L 

PROVIDER: S-EPMC12274536 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature