Multi-component reactions via copper(I) difluorocarbene as carbonyl source for constructing α-aminoamide derivatives.

ABSTRACT: Difluorocarbene, an important reactive intermediate in organic synthesis, exhibits intriguing properties and synthetic versatility. However, great challenges in modulating reaction pathways limit its widespread application in synthetic chemistry. While metal-catalyzed difluorocarbene transfer offers a promising strategy but remains a formidable challenge. Herein, we disclose a copper-mediated multicomponent reaction of amine, aldehyde and BrCF₂CO₂K for synthesis of α- aminoamide derivatives, wherein copper-difluorocarbene serve as carbonyl source. Control experiments and DFT calculations support the pathway initiated by formation of a copper-difluorocarbene from BrCF₂CO₂K, followed by nucleophilic attack of the amine to produce an ammonium ylide,

SUBMITTER: Li J 

PROVIDER: S-EPMC12274583 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature