Prostate cancer incidence and outcomes among Vietnam veterans receiving care in the Veterans Health Administration.

ABSTRACT:

Background

Agent Orange exposure (AOE) is considered a presumptive cause of prostate cancer (PCa) in the Veterans Affairs (VA) population; however, cohort studies reported inconsistent associations of AOE and PCa incidence and outcomes. In this nationwide cohort study, Vietnam veterans who received VA care were evaluated for associations of AOE and PCa incidence and adverse outcomes.

Methods

Vietnam veterans 17-25 years old during military service (1962-1971) who received VA health care between 2005 and 2020 were stratified by presumptive AOE assigned by the VA and followed until death from any cause or censoring on September 31, 2023. Multivariable Cox models permitted estimation of adjusted hazard ratios (aHRs) of AOE with PCa incidence, de novo metastasis (DNM), any metas

SUBMITTER: Green-Lott AY 

PROVIDER: S-EPMC12274657 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature