Anti-fatigue adhesive non-swelling hydrogel constructed by covalent topological structure and micro-nano gel for stretchable bioelectronics.

ABSTRACT: Hydrogel adhesives are rapidly emerging as a promising candidate toward flexible bioelectronics due to their adhesive characteristics and tissue-like mechanical properties. However, current hydrogel adhesives manifest weak anti-fatigue adhesion and an inability to ensure long-term integration of bioelectrodes on wet and dynamic tissue surfaces because they are constrained by their high swelling ratio and exclusive formation of covalent bonds at the tissue interface and its own weak cohesion. Here, we for the first time develop covalent bond topological adhesion paired with double covalent bond cross-linking in hydrogel to enhance cohesive force and adhesive force, achieving excellent anti-fatigue tissue adhesion and adhesive's capacity to follow significant tissue deformation. The adhesive

SUBMITTER: Tian G 

PROVIDER: S-EPMC12274688 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature