Comparison of proton and photon therapy in stereotactic arrhythmia radioablation for ventricular tachycardia.

ABSTRACT:

Background and purpose

Ventricular tachycardia (VT) is a life-threatening arrhythmia commonly treated with catheter ablation; however, some cases remain refractory. Stereotactic arrhythmia radioablation (STAR) offers a non-invasive alternative. While photon-based STAR is effective, proton therapy may improve dose conformity and spare critical organs at risk (OARs), including the heart itself. The aim of this study was to compare the dose-volume metrics between proton and photon therapy for VT.

Materials and methods

We retrospectively analyzed 34 VT patients who received photon STAR. Proton STAR plans were generated using robust optimization in a commercial treatment planning system to deliver the same prescription dose of 25 Gy in a single fraction. Dose-volume metrics, incl

SUBMITTER: Shah KD 

PROVIDER: S-EPMC12274703 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature