Assessment of ex vivo antimalarial drug efficacy in African Plasmodium falciparum parasite isolates, 2016-2023: a genotype-phenotype association study.

ABSTRACT:

Background

Given the altered responses to both artemisinins and lumefantrine in Eastern Africa, monitoring antimalarial drug resistance in all African countries is paramount.

Methods

We measured the susceptibility to six antimalarials using ex vivo growth inhibition assays (IC₅₀) for a total of 805 Plasmodium falciparum isolates obtained from travellers returning to France (2016-2023), mainly from West and Central Africa. Isolates were sequenced using molecular inversion probes (MIPs) targeting forty-three genes across the parasite genome, of which nineteen are drug resistance genes.

Findings

Ex vivo susceptibility of all assessed antimalarial compounds was consistent with their potent activity. The median IC₅₀ values for the six drugs were 1.1 n

SUBMITTER: Rosado J 

PROVIDER: S-EPMC12274720 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature