Salivary MicroRNAs as Potential Noninvasive Biomarkers for the Diagnosis of Nasopharyngeal Carcinoma: Protocol for a Scoping Review.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) is the fourth-most-prevalent cancer in both Indonesia and Asia. Globally, an estimated 133,354 cases and 80,008 deaths were attributed to NPC in 2020. Early diagnosis plays a key role in managing NPC. Molecules found in bodily fluids, such as saliva, contain compounds (including microRNAs [miRNAs]) that can aid in detecting diseases like NPC. More studies on the expression, role, use, and accuracy of salivary miRNAs as potential diagnostic biomarkers of NPC are needed.

Objective

This protocol provides a framework for conducting a scoping review aimed at mapping the expression, role, use, and diagnostic accuracy of specific salivary miRNAs as potential diagnostic biomarkers of NPC.

Methods

The guidelines established by the JBI

SUBMITTER: Wibowo AS 

PROVIDER: S-EPMC12274780 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature