Oral olsalazine/ellagic acid/ZnCl₂-modified in situ-forming hydrogels alleviates anxiety/depression-like symptoms and brain neural activity in colitis mice.

ABSTRACT: Inflammatory bowel disease (IBD) is a kind of chronic non-specific intestinal inflammatory disease, which accompanied by various abnormal psychological states, such as anxiety and depression. Nevertheless, the pathogenesis of IBD with depression is still unclear. Herein, we synthesized an enable a drinkable, liquid in situ-forming hydrogel, which form directly in the stomach through sequential ingestion of a crosslinker solution of CaCl₂ and ε-poly-l-lysine (ε-PL), followed by a drug-containing polymer solution of sodium alginate (SA). Using olsalazine (Olsa) and antioxidant (ellagic acid (EA) and ZnCl₂) as small molecule drug (referred as Olsa/EA/Zn), the resulting hydrogel (referred as Olsa/EA/Zn@SA/ε-PL hydrogel) could form rapidly in gastric fluid and exhibit rema

SUBMITTER: Li T 

PROVIDER: S-EPMC12274806 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature