Colchicine inhibits vascular calcification by suppressing inflammasome activation through the enhancement of the Sirt2-PP2Ac signaling pathway.

ABSTRACT: Colchicine (Col) is a traditional herbal medicine derived from the plant Colchicum autumnale. With the property of anti-inflammation, Col has demonstrated certain therapeutic effects in cardiovascular diseases. Vascular calcification is positively related to the morbidity and mortality of cardiovascular diseases. However, the specific cardiovascular conditions for which Col is effective remain unclear, particularly its impact on vascular calcification. In this study, we used high phosphate to induce calcium deposition in vascular smooth muscle cells and Vitamin D₃ plus nicotine or 5/6 nephrectomy along with high phosphate diet to construct vascular calcification mouse models. Our results showed that Col reduced calcium accumulation in vitro, and vascular calcification both in ex

SUBMITTER: Yang S 

PROVIDER: S-EPMC12274824 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature