Select early growth response (Egr) isoforms augment hypoxia inducible factor 2 (HIF-2) regulation of erythropoietin (Epo) gene expression in mammals.

ABSTRACT: Hypoxia inducible factors (HIFs) are heterodimeric, oxygen-sensitive, stress-responsive transcription factors in vertebrates composed of one of three alpha components conferring oxygen sensitivity and one of four beta components required for dimerization and DNA binding. The founding alpha member, HIF-1α, is ubiquitously expressed and regulates numerous target genes required for cellular function under physiological hypoxic states. In comparison, HIF-2α is more restricted in its expression, but nevertheless is also required for normal physiological function. The prototypical HIF-2 target gene is erythropoietin (Epo), one of the most highly hypoxia-inducible genes in mammals and in Hep3B cells, a model cell line used to study hypoxia-inducible gene regulation. However, despite cell culture

SUBMITTER: Nagati JS 

PROVIDER: S-EPMC12274846 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature