Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic review.

ABSTRACT:

Background

Cyanotic congenital heart disease (CCHD) affects over 3 million individuals globally and can progress to heart failure. Mitochondrial dysfunction is well established in adult heart failure and is also a central feature of CCHD. CCHD cyanosis itself contributes to further mitochondrial dysfunction. Systems biology methods detail the epigenomic, transcriptomic, and metabolomic profile of biological samples. This systematic review highlights CCHD systems biology literature related to mitochondrial dysfunction.

Methods

OVID/Medline was searched between January 2010 and June 2025. Studies implementing untargeted systems biology methods in CCHD tissue or plasma were included. Genes with differential expression between CCHD and unaffected controls were pooled and analyse

SUBMITTER: Elbatarny M 

PROVIDER: S-EPMC12274853 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature