ROS-scavenging hydrogen nanotherapy simultaneously targets inflammation and pain in rheumatoid arthritis.

ABSTRACT: Relieving pain while treating rheumatoid arthritis (RA) is a pressing clinical need to improve satisfaction of patients, which has not received the due attention and solution. Herein, we propose a strategy to kill two birds with one stone, for which we emphasize synergetic therapeutic outcome of analgesia and inhibiting RA progression through introducing hydrogen nanogenerator to scavenge reactive oxygen species (ROS) at lesion locations. This system exhibited efficient ROS scavenging and reducing apoptosis of C17.2 cells. In a complete Freund's Adjuvant-induced RA mouse model, this controlled hydrogen release behavior significantly downregulated pro-inflammatory mediators, protecting chondrocytes from apoptosis and preventing cartilage degradation. Furthermore, hydrogen therapy could effe

SUBMITTER: Wu Q 

PROVIDER: S-EPMC12274877 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature