Echocardiographic effects of sodium-glucose cotransporter 2 inhibitors in single ventricle circulatory failure.

ABSTRACT:

Background

Single ventricle patients are at high risk of developing circulatory failure. There is limited evidence for pharmacological treatment. This study assessed the echocardiographic changes in ventricular function during sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy in patients with single ventricle failure (SVF).

Methods

SVF patients with a baseline transthoracic echocardiogram within six months before starting SGLT2i and at least one echocardiographic examination within twelve months follow-up were included from a real-world international registry of adult congenital heart disease patients on SGLT2i. Mixed models were used to evaluate longitudinal changes in ventricular function and differences between patients with SVF with ≥ moderately reduced systolic

SUBMITTER: Neijenhuis RML 

PROVIDER: S-EPMC12274904 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature