Population attributable fractions of modifiable dementia risk factors for cognitive impairment-the ELSA-Brasil cohort study.

ABSTRACT:

Background

Population attributable fractions (PAF) of modifiable dementia risk factors are rarely estimated in low- and middle-income countries. We aim to estimate the relative risk (RR) for cognitive impairment and calculate the PAF in the Estudo Longitudinal da Saúde do Adulto (ELSA-Brasil).

Methods

We analyzed adults aged 35-74 at the baseline (2008-2010) and wave 3 (2017-2019). We estimated the prevalence of eight modifiable dementia risk factors at baseline: hypertension, physical inactivity, diabetes, depression, obesity, low education, smoking, and excessive alcohol consumption. Cognition was evaluated at baseline and wave 3 using six standardized tests for the Brazilian Portuguese. A global cognitive score from the individual cognitive tests was created using

SUBMITTER: Castilhos RM 

PROVIDER: S-EPMC12274917 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature