An injectable and dual-crosslinked hydrogel for controlled and permanent vascular embolization.

ABSTRACT: Embolization that deliberately blocks target blood vessels through the delivery of embolic agents has emerged as a preferred therapy for various vascular-related diseases. Although various embolic materials are available in clinical practice, including solid and liquid embolic agents, their effectiveness remains limited in target vessels with broad size ranges and complex architectures. These limitations pose challenges in achieving controlled and durable embolization at target sites. To address these issues, we develop an advanced physically/chemically dual-crosslinked hydrogel (DC-gel) composed of thermosensitive poly(ethylene glycol)-poly(_D-amino acid) copolymers and triethoxysilane-capped 4-arm poly(ethylene glycol) macromolecule crosslinkers, which exhibits superior injecta

SUBMITTER: Wang X 

PROVIDER: S-EPMC12274945 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature