Myeloid MyD88 Mediates Macrophage Infiltration and Activation in Ang II-Induced Cardiac Hypertrophy.

ABSTRACT: Hypertension is the leading cause of cardiac remodelling and heart failure. Recent evidence has highlighted the role of the non-hemodynamic function of angiotensin II in hypertension. MyD88 is the canonical adaptor of TLRs and IL-1Rs, which serves as the central node in regulating inflammatory responses. Previous studies reported the opposite roles of MyD88 in hypertension. In this study, we aimed to determine the role of MyD88 and the underlying mechanisms in hypertension. Cardiomyocyte-specific MyD88 knockout mice, macrophage-specific MyD88 knockout mice, and MyD88 inhibitor-treated mice were challenged with Ang II infusion to establish a cardiac remodelling model. An inflammatory cytokine array was used to determine the internal mediators. Our results showed that cardiomyocyte MyD88 def

SUBMITTER: Lin K 

PROVIDER: S-EPMC12274960 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature