Clinical and Imaging Correlates of Medication Reduction in Globus Pallidus Stimulation for Parkinson's Disease.

ABSTRACT:

Background

The magnitude and factors associated with levodopa equivalent daily dose (LEDD) reduction in deep brain stimulation (DBS) of the globus pallidus interna (GPi) for Parkinson's Disease (PD) remain unclear.

Objective

To investigate LEDD reduction in GPi DBS and its correlation with anatomical/clinical characteristics.

Methods

A consecutive cohort of 74 patients who had undergone GPi DBS was analyzed. Regression and probabilistic efficacy mapping were performed to evaluate factors predicting LEDD reduction.

Results

32.4% of GPi individuals experienced significant LEDD reduction (>30%). Anteromedial GPi stimulation was associated with higher LEDD reduction.

Conclusion

Anteromedial stimulation of the GPi appears to be associated with medication redu

SUBMITTER: Di Luca DG 

PROVIDER: S-EPMC12275007 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature