Glucose deposited during goose fatty liver formation inhibits inflammation in goose fatty liver by reducing the interaction between PKA and IκB.

ABSTRACT: Protein Kinase A (PKA) is found in a wide range of body tissues and is involved in various cellular activities. PKA has been observed to interact with key proteins in the nuclear factor kappa-B (NF-κB) pathway to activate the pathway, thereby triggering an inflammatory response. However, the role of PKA in the anti-inflammatory mechanism of goose fatty liver remains to be elucidated. A total of 16 healthy 70-day-old male Lander geese were randomly divided into the control and overfeeding groups. Next, goose primary hepatocytes were treated with 200 mmol/L glucose. The protein levels of p-IκB, PKA and tumor necrosis factor alpha (TNFα) in the liver and hepatocytes, as well as the interaction of p-IκB and PKA were detected. Finally, the hepatocytes were treated with a combination of 200 mmol

SUBMITTER: Lv M 

PROVIDER: S-EPMC12275047 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature