Changes in splenic volumes following stereotactic ablative radiotherapy (SABR) to adrenal tumors.

ABSTRACT:

Purpose

Splenic irradiation can result in life-threatening infections. Updated dose constraints have been recommended for patients undergoing chemoradiotherapy and conventional radiotherapy but splenic constraints were not specified in trials of stereotactic ablative radiotherapy (SABR). We studied splenic doses in patients undergoing SABR for adrenal metastases and late changes in splenic volume (SV).

Material and methods

Patients treated with breath-hold MR-guided SABR for adrenal metastases were identified from an Ethics-approved database. Splenic dose constraints were not routinely used. The spleen was delineated retrospectively on both breath-hold CT and MR-scans. Mean spleen dose (MSD) and relative V_5-10-20-30Gy values were derived from the baseline plan. SV

SUBMITTER: Giraud N 

PROVIDER: S-EPMC12275063 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature