A multi-modal study on cerebrovascular dysfunction in cognitive decline of de novo Parkinson's disease.

ABSTRACT:

Background

Vascular risk factors are increasingly implicated in Parkinson's disease (PD), but the role of altered cerebrovascular dysfunction in early-stage PD remains unclear. Here, we investigated resting-state cerebrovascular reactivity (RS-CVR), cerebral blood flow (CBF), arterial morphological changes, and corresponding alterations in functional connectivity density (FCD) in de novo PD patients with different cognitive status.

Methods

25 de novo PD patients with mild cognitive impairment (PD-MCI), 34 with normal cognition (PD-NC), and 48 healthy controls (HCs) underwent neuropsychological assessments and multimodal MRI. CBF derived from arterial spin labeling, RS-CVR and FCD generated from resting-state functional MRI and the arterial morphology extracted from the magni

SUBMITTER: Li H 

PROVIDER: S-EPMC12275129 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature