Polyphenol-based self-assembled nanoparticles treating uveitis by inflammation-oxidative stress suppression.

ABSTRACT: The breakdown of the blood-retinal barrier (BRB), which induces vascular leakage, represents a critical pathological hallmark underlying severe vision loss in uveitis. The inflammatory response triggers phenotypic alterations in microglia, driving excessive reactive oxygen species (ROS) production and initiating a pro-inflammatory cytokine storm involving multiple inflammatory mediators. This synergistic interaction establishes a self-amplifying pathological cascade that ultimately leads to BRB dysfunction. As a natural bioactive compound, epigallocatechin gallate (EGCG) demonstrates well-established ROS scavenging capacity, while metformin (MET), a clinically approved antidiabetic agent, effectively inhibits inflammatory responses. We used a self-assembly strategy to construct multifuncti

SUBMITTER: Chen H 

PROVIDER: S-EPMC12275131 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature