Micronized purified flavonoid fraction (daflon) improves sexual function by modulating NF-kB /NO/cGMP and steroidogenic signaling in cisplatin-treated male Wistar rats.

ABSTRACT: Cisplatin is known to induce sexual dysfunction by suppressing testosterone levels. It also upregulates nuclear factor-kappa B (NF-kB), which mediates nitric oxide (NO)-dependent endothelial dysfunction. This study evaluated the effects of daflon, a micronized purified flavonoid fraction that contains diosmin and hesperidin, on the NF-kB/NO/cyclic guanosine monophosphate (cGMP) and steroidogenic signaling pathways in cisplatin-induced male sexual dysfunction. Thirty-two male Albino Wistar rats were randomly assigned to four groups: vehicle-treated, daflon-treated, cisplatin-treated, and cisplatin plus daflon-treated. Cisplatin administration resulted in impaired sexual function, characterized by prolonged latencies for mounting, intromission, and ejaculation, as well as a decrease in matin

SUBMITTER: Re A 

PROVIDER: S-EPMC12275157 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature