Expression and clinical significance of MCF2L-AS1 in stomach adenocarcinoma.

ABSTRACT:

Background

Stomach Adenocarcinoma (STAD) poses a significant burden due to its high prevalence and costly, painful treatments, exerting considerable pressure on individuals.

Objectives

This study intends to explore novel therapeutic targets to enhance prognosis and alleviate patient stress.

Materials and methods

Quantitative Real-time Polymerase Chain Reaction was employed to detect MCF2L-AS1 expression in STAD tissues and cell lines. The correlation between this expression and patients' clinical conditions and prognosis was analyzed utilizing the Chi-squared test and Kaplan-Meier method. To investigate the regulatory mechanism of MCF2L-AS1, the Luciferase reporter gene system and transfection experiments were implemented. Cellular behaviors were analyzed through CCK8

SUBMITTER: Sun C 

PROVIDER: S-EPMC12275226 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature