High-density lipoprotein cholesterol, particles and subspecies and the risk of chronic kidney disease: The PREVEND prospective study.

ABSTRACT:

Background

The relationships between high-density lipoprotein cholesterol (HDL-C), HDL particle concentration (HDL-P), and HDL subspecies with the development of chronic kidney disease (CKD) have not been well characterized. This study aimed to examine these associations and evaluate the role of alcohol consumption as a potential confounder or effect modifier.

Methods

Data was analyzed from 4,179 individuals (mean age: 52 years; 47.6% male) participating in the PREVEND cohort. Baseline measurements included HDL-P and its subfractions (small, medium, and large), quantified by nuclear magnetic resonance spectroscopy, and self-reported alcohol intake. Incident CKD was defined using criteria from the KDIGO guidelines. Cox proportional hazards models were used to estimate hazard

SUBMITTER: Kunutsor SK 

PROVIDER: S-EPMC12275243 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature