Irisin regulates integrin αvβ5/FAK/ERK to inhibit neutrophil extracellular traps formation and reduce pancreatic beta-cells pyroptosis in type 2 diabetes mellitus.

ABSTRACT:

Background

Dysregulation of neutrophil extracellular traps (NETs), through overproduction or poor clearance, can lead to tissue damage and is linked to inflammatory conditions like type 2 diabetes mellitus (T2DM). Irisin, a hormone believed to modulate energy metabolism and enhance insulin sensitivity, holds promise as a potential treatment for T2DM. This study aims to investigate the role of Irisin in alleviating β-cell pyroptosis by inhibiting NETs formation and elucidating the underlying molecular mechanisms.

Methods

C57BL/6J mice were used to establish T2DM through a high-fat diet and streptozotocin injection. Glucose metabolism was evaluated using oral glucose tolerance tests and fasting plasma insulin measurements. Histological analysis of pancreatic tissue was carried

SUBMITTER: Tan A 

PROVIDER: S-EPMC12275247 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature