Cardiac digital twins: a tool to investigate the function and treatment of the diabetic heart.

ABSTRACT: Diabetes increases the risk of cardiovascular disease (CVD) due to its multi-scale and diverse effects on cardiomyocyte metabolism and function, the circulation, and the kidneys. The complex relationship between organ systems affected by diabetes and associated comorbidities leads to challenges in estimating cardiovascular risk and stratifying optimal treatment strategies at the individual patient level. Most recently, sodium-glucose transport protein 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP1) receptor agonists have been shown to offer substantial cardiac benefits. However, the direct or indirect mechanisms through which these agents protect the heart remain unclear, posing a challenge to patient selection. Amidst a growing burden of diabetes and increased therapeutic armament

SUBMITTER: Strocchi M 

PROVIDER: S-EPMC12275252 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature