Prenatal diagnosis and genetic assessment of fetuses with single umbilical artery using chromosomal microarray analysis: a seven-year single-center retrospective study.

ABSTRACT:

Background

The inherited causes behind fetuses with a single umbilical artery (SUA) are still poorly understood, largely because published studies are scarce. In the present research, efforts were made to uncover the genetic factors at play and to assess how SUA influences pregnancy outcome.

Methods

A retrospective review was performed on 5,014 pregnant individuals who underwent prenatal diagnostic testing between September 2017 and April 2023. Of these, 123 fetuses were found to have SUA. Amniocentesis was carried out in all affected cases, with samples analyzed via conventional karyotyping and chromosomal microarray analysis (CMA) to detect any chromosomal abnormalities.

Results

In the present study, four cases of chromosome aneuploid and two cases of chromosomal st

SUBMITTER: Zhuang J 

PROVIDER: S-EPMC12275279 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature