Functional study of laminin subunit α5 in high-grade serous ovarian cancer.

ABSTRACT:

Objective

To investigate the expression of LAMA 5 (laminin subunit α5) in high-grade serous ovarian cancer and its relationship with the prognosis of ovarian cancer patients.

Methods

The expression of LAMA5 in high-grade serous ovarian cancer was explored through the ovarian cancer sample information in multiple databases and real-time fluorescent quantitative PCR (Real Time Quantitative PCR, RT-qPCR). Effect of LAMA5 on the proliferation and migration of ovarian cancer cells. The possible mechanism of LAMA 5 affecting the malignant process of ovarian cancer was searched by GSEA analysis.

Results

Based on bioinformatics analysis and RT-qPCR verification in multiple databases, it was found that LAMA5 was highly expressed in serous ovarian cancer, which was related to c

SUBMITTER: Tianli W 

PROVIDER: S-EPMC12275312 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature