Proton beam radiation therapy and the overall survival of adult and pediatric patients diagnosed with central nervous system tumors.

ABSTRACT:

Background

There is an increased interest in using proton beam radiation therapy (PBT) in Central nervous system (CNS) tumors. However, no clear information exists about the association of PBT with the overall survival (OS) of patients diagnosed with CNS tumors. The current study aims to investigate the association of PBT with the OS of patients with CNS tumors.

Methods

This study included patients from the National Cancer Database diagnosed with CNS tumors between 2004 and 2022. Multivariable Cox regression analysis was used to assess the OS. The multivariable analyses were adjusted for age at diagnosis, sex, race, RT dose, health insurance, histology, education, income, comorbidity score, surgery, chemotherapy, and year of diagnosis.

Results

Of the 162,506 patients,

SUBMITTER: Amin S 

PROVIDER: S-EPMC12275320 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature