HucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery.

ABSTRACT:

Background

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by absolute insulin (INS) deficiency. As key components of the immune system, macrophages play critical roles in T1DM-associated pancreatic β-cell damage and multiorgan inflammatory injuries. Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-EXOs) have emerged as promising therapeutic agents for immune-related disorders due to their immunomodulatory properties and favorable safety profile. However, systematic investigations into the therapeutic potential of hucMSC-EXOs in T1DM are lacking. This study aimed to evaluate the systemic anti-inflammatory effects of hucMSC-EXOs in T1DM and identify their key bioactive components.

Methods

T1DM was induced in C57BL/6 male

SUBMITTER: Chen X 

PROVIDER: S-EPMC12275347 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature