High altitude might increase risk of incident frailty in older adults: a nationwide longitudinal survey.

ABSTRACT:

Background

The number of residents at high altitude is high globally, yet few studies have been conducted on the association between altitude and incident frailty. We evaluated the prospective association and dose-response relationship between altitude and frailty among Chinese older adults.

Methods

We conducted a prospective cohort study using data from the China Health and Retirement Longitudinal Survey (CHARLS) from 2013 to 2018, enrolling 4065 participants aged ≥ 60 years at baseline. Frailty was assessed using a frailty index (FI) containing 29 health deficit indicators constructed. Cox proportional hazard regression and linear mixed model were used to analyze the association of altitude with frailty. Restricted Cubic Spline regression was used to assess the dose-respon

SUBMITTER: Dong Y 

PROVIDER: S-EPMC12275372 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature