Meta-analysis identifies the major impact of patient classification on the ACPA association with rheumatoid arthritis-associated interstitial lung disease (RA-ILD).

ABSTRACT:

Background

We need screening for RA patients at high risk of RA-ILD to prevent the associated decrease in life quality and survival. The proposed screenings disagree regarding the anti-citrullinated protein antibodies (ACPA) because of their inconsistent association across recent studies. Therefore, we hypothesized that meta-analysis of the published reports should reveal clues explaining the heterogeneity of results, helping us progress in RA-ILD early detection.

Objectives

We aimed to discover the factors accounting for the variability of the ACPA association in the published reports.

Methods

We searched the Web of Science and PubMed databases for studies reporting ACPA in RA-ILD and RA-control groups. The identified studies were analyzed using meta-analysis and met

SUBMITTER: Kaczmarczyk B 

PROVIDER: S-EPMC12275375 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature