Triglyceride-glucose index and cancer risk: a prospective cohort study in Taiwan.

ABSTRACT:

Background

Insulin resistance (IR) is a key metabolic abnormality associated with adverse health outcomes, including increased cancer risk. The triglyceride-glucose (TyG) index, a validated surrogate marker of IR, has been linked to metabolic dysfunction; however, its association with cancer risk in large population-based cohorts remains unclear. This study aimed to evaluate the relationship between TyG index and cancer risk in Taiwanese population.

Methods

We analyzed 150,592 participants from the Taiwan Biobank, among whom 148,809 were linked to the Taiwan Cancer Registry (2011-2022) for cancer incidence tracking. Cancer risk was assessed across TyG quartiles over a median follow-up of 5.7 years (IQR: 3.4-7.6). Hazard ratios (HRs) and 95% confidence intervals (CIs) were es

SUBMITTER: Yeh HY 

PROVIDER: S-EPMC12275392 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature