Evolutionary origin of the frameshift sites in the ribosomal frameshifting genes of Euplotes.

ABSTRACT:

Background

Programmed ribosome frameshifting is a translational recoding event in which ribosomes slip forward or backward along the mRNA. Although genes utilizing programmed ribosomal frameshifting for their expression have been found in most organisms, such genes are commonly considered rare. However, previous studies indicated that both +1 and +2 ribosomal frameshifting are frequently required for the expression of genes in the ciliates Euplotes. In this study, we explored the possible evolutionary origin of the frameshift sites by comparative transcriptome and genome analyses.

Results

We sequenced the transcriptomes of different Euplotes octocarinatus strains and performed comparative analyses of the frameshift sites. Finally, a total of 147 non-conserved frameshift site

SUBMITTER: Wang RL 

PROVIDER: S-EPMC12275403 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature