Serum LH levels before progesterone administration significantly affect pregnancy outcomes in hormone replacement therapy-frozen-thawed embryo transfer cycles.

ABSTRACT:

Background

In hormone replacement therapy-frozen-thawed embryo transfer (HRT-FET) cycles, endogenous LH levels may still rise, and the relationship between this and pregnancy outcomes is unclear. The purpose of this study was to investigate the correlation between the serum LH levels before progesterone administration in HRT-FET cycles and the live birth rate (LBR).

Methods

A total of 13 720 HRT-FET cycles were divided into four groups based on serum LH levels according to the quartiles. Meanwhile, subgroup analyses were performed based on the use of pituitary down-regulation to evaluate the independent effects of serum LH levels on pregnancy outcomes. We used multivariate logistic regression analysis to adjust for potential confounding factors.

Results

In the overall

SUBMITTER: Han X 

PROVIDER: S-EPMC12275408 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature