Causal association between immunoglobulin G N-glycosylation patterns and diabetic complications: two-sample mendelian randomization.

ABSTRACT:

Background

To elucidate the correlation between immunoglobulin G (IgG) N-glycosylation patterns (IGPs) and diabetes complications, including diabetic nephropathy (DN), diabetic retinopathy (DR) and diabetic maculopathy (DM). We performed a two-sample Mendelian randomization (MR) study.

Methods

We obtained genome-wide association studies (GWAS) summary statistics related to 77 IGPs and diabetic complications from the MRC Human Genetics Unit and the FinnGen consortium. In our two-sample MR, genetic variants associated with IGPs were used to estimate correlations. The inverse-variance weighted (IVW) method was used as the primary analysis. Various complementary methods, including MR-Egger, weighted median (WM), and weighted mode were implemented to detect the causal relationshi

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12275434 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature