Effectiveness of B Vitamins and Their Interactions with Aspirin in Improving Cognitive Functioning in Older People with Mild Cognitive Impairment: Pooled Post-Hoc Analyses of Two Randomized Trials.

ABSTRACT:

Background and objectives

A randomized placebo-controlled trial found a significant negative interaction between aspirin and B vitamins in cognitive functioning in older people with mild cognitive impairment (MCI). To validate this finding, we pooled data of this trial with that of a similar B-vitamin trial (VITACOG) to examine the effectiveness of B vitamins and their interactions with aspirin in improving global cognitive functioning and slowing brain atrophy in older people with MCI.

Design

Pooled post-hoc analyses of two randomized placebo-controlled trials.

Participants

In total, 545 older people with MCI were included in the study.

Intervention

Placebo or B-vitamin supplements (vitamin B12, folic acid with or without vitamin B6) for 24 months.

Measurem

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12275523 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature