Sex-Specific Associations of Dietary Iron Intake with Brain Iron Deposition on Imaging and Incident Dementia: A Prospective Cohort Study.

ABSTRACT:

Objectives

The study aimed to evaluate the association of dietary iron intake with incident dementia and brain iron deposition.

Design/setting/participants

We included dementia-free participants from the UK Biobank who completed at least one 24-hour dietary recall at study baseline (2009-2012) and were followed up to 2021. Incident dementia was determined through linkage to medical records and death registries. Brain MRI was conducted in a subgroup of participants since 2014, with T2* measurements being used as indicators of brain iron deposition.

Measurements

Cox proportional hazard models were used to assess the associations of high (top quintile) and low (bottom quintile) versus medium (quintile 2 to 4) level of dietary iron intake with incident dementia, respectiv

SUBMITTER: Pan W 

PROVIDER: S-EPMC12275542 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature