Rapid Progression of Aortic Calcification in Older Men with Low Appendicular Lean Mass and Poor Physical Function.

ABSTRACT:

Objectives

Assessment of the progression of abdominal aortic calcification (AAC) may be a surrogate marker of the impact of physical function on cardiovascular risk. Our aim was to assess the risk of rapid AAC progression in older men with low relative appendicular lean mass (RALM) and poor physical function.

Design

Prospective cohort study.

Setting

Community-dwelling older men.

Participants

621 men aged 50-85 followed prospectively (baseline, 3 and 7.5 years).

Measurements

Body composition was assessed by DXA. Poor physical function was defined as incapacity to perform ≥1 of 5 clinical tests (balance, muscle strength). AAC was assessed using Kauppila's semiquantitative score. Reclassification improvement was assessed by comparing the areas under the cur

SUBMITTER: Szulc P 

PROVIDER: S-EPMC12275551 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature