Myokines and Biomarkers of Frailty in Older Inpatients with Undernutrition: A Prospective Study.

ABSTRACT:

Background

Population aging might increase the prevalence of undernutrition in older people, which increases the risk of frailty. Numerous studies have indicated that myokines are released by skeletal myocytes in response to muscular contractions and might be associated with frailty. This study aimed to evaluate whether myokines are biomarkers of frailty in older inpatients with undernutrition.

Methods

The frailty biomarkers were extracted from the Gene Expression Omnibus and Genecards datasets. Relevant myokines and health-related variables were assessed in 55 inpatients aged ≥ 65 years from the Peking Union Medical College Hospital prospective longitudinal frailty study. Serum was prepared for enzyme-linked immunosorbent assay using the appropriate kits. Correlations betwe

SUBMITTER: Liu H 

PROVIDER: S-EPMC12275702 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature