The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults.

ABSTRACT:

Background/objectives

Apolipoprotein (ApoE ε4) status has been associated with various cardiovascular diseases and Alzheimer's Disease. Some studies have found a possible relationship between the presence of an ApoE ε4 allele and the decrease of motor function in healthy older adults. The objective of this study was to measure the cross-sectional and prospective associations of ApoE ε4 status with lower limb function and handgrip strength in older adults.

Design

Longitudinal observational study using data from a randomized controlled trial.

Setting

Community-dwelling older adults.

Participants

1300 older adults (≥70 years old) with ApoE ε4 status from the Multidomain Alzheimer's Preventive Trial (MAPT) were followed for three years.

Measurements

Lower-li

SUBMITTER: Maltais M 

PROVIDER: S-EPMC12275786 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature