CTV-MIND: A cortical thickness-volume integrated individualized morphological network model to explore disease progression in temporal lobe epilepsy.

ABSTRACT: Temporal lobe epilepsy (TLE) is a progressive brain network disorder. Elucidating network reorganization and identifying disease progression-associated biomarkers are crucial for understanding pathological mechanisms, quantifying disease burden, and optimizing clinical strategies. This study aimed to investigate progressive changes in TLE by constructing a novel individualized morphological brain network based on T1-weighted structural magnetic resonance imaging (MRI). MRI data were collected from 34 postoperative seizure-free TLE patients and 28 age- and sex-matched healthy controls (HC), with patients divided into LONG-TERM and SHORT-TERM groups. Individualized morphological networks were constructed using the Morphometric INverse Divergence (MIND) framework by integrating cortical thick

SUBMITTER: Liu X 

PROVIDER: S-EPMC12275856 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature